Protein Details: Small conductance calcium-activated potassium channel protein 1
Protein ID
ICDB_Pro_0690
Protein Name
Small conductance calcium-activated potassium channel protein 1
Gene Name
Kcnn1; Sk1
Organism
Rattus norvegicus (Rat)
Length
536 amino acids
AlphaFoldDB
AF-P70606-F1-model_v4.pdb
Function
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)
Sequence
MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Widely expressed including brain.
DOI ID
10.1073/pnas.94.20.11013; 10.1126/science.273.5282.1709; 10.1073/pnas.0600895103
RefSeq
NP_062186.1; XP_017455721.1